Newborn granule cells in the ageing dentate gyrus
نویسندگان
چکیده
منابع مشابه
Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus
Dentate gyrus granule cells (GCs) have been suggested to synthesize both GABA and glutamate immediately after birth and under pathological conditions in the adult. Expression of the GABA synthesizing enzyme GAD67 by GCs during the first few weeks of postnatal development may then allow for transient GABA synthesis and synaptic release from these cells. Here, using the GAD67-EGFP transgenic stra...
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Granule cells of the mammalian dentate gyrus normally form a discrete layer, and virtually all granule cells migrate to this location. Exceptional granule cells that are positioned incorrectly, in 'ectopic' locations, are rare. Although the characteristics of such ectopic granule cells appear similar in many respects to granule cells located in the granule cell layer, their rare occurrence has ...
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Hippocampal granule cells are critical relay stations to transfer spatial information from the entorhinal cortex into the hippocampus proper. Therefore, the integrative properties of the small-caliber granule cell dendrites were examined in this thesis, using a combination of dual somato-dendritic patch-clamp recordings and two-photon glutamate uncaging. These experiments revealed unusual integ...
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We used whole cell patch clamp and gramicidin perforated patch recordings in hippocampal slices to study gamma-aminobutyric acid (GABA) currents in granule cells (GCs) from juvenile rat dentate gyrus (DG). GCs are generated postnatally and asynchronously such that they can be detected at different stages of their maturation in DG within the first month. In contrast, inhibitory interneurons are ...
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A substantial fraction of adult-generated granule cells in the dentate gyrus survive and integrate into the existing neuronal network. These newborn neurons must navigate the environment of the adult brain, a setting that is presumably less optimized for neuronal maturation compared with that in the developing brain. We used EGFP (enhanced green fluorescent protein) expression in newborn granul...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2008
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2008.154807